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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Cytochrome P450 (CYPs)-CYP3cide
CYP3cide

Chemical Structure : CYP3cide

CAS No.: 1390637-82-7

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CYP3cide (PF-4981517, PF-04981517)

货号: PC-23802Not For Human Use, Lab Use Only.

CYP3cide (PF-04981517) is a potent, efficient, and specific time-dependent inhibitor of cytochrome P4503A4 (CYP3A4) with IC50 of 0.03 uM, >500-fold selective over CYP3A5 and CYP3A7.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

CYP3cide (PF-04981517) is a potent, efficient, and specific time-dependent inhibitor of cytochrome P4503A4 (CYP3A4) with IC50 of 0.03 uM, >500-fold selective over CYP3A5 and CYP3A7.
CYP3cide (PF-04981517) has an apparent K(I) between 420 and 480 nM with a maximal inactivation rate (k(inact)) equal to 1.6 min⁻¹.

物理化学性质&存储条件

分子量 456.60
分子式 C26H32N8
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1H-Pyrazolo[3,4-d]pyrimidine, 1-methyl-3-[1-methyl-5-(4-methylphenyl)-1H-pyrazol-4-yl]-4-[(3S)-3-(1-piperidinyl)-1-pyrrolidinyl]-

参考文献

1. Walsky RL, et al. Drug Metab Dispos. 2012 Sep;40(9):1686-97.

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