| Cat. No. |
Product Name |
Information |
| PC-35082 |
Cathepsin B inhibitor RC1
Cathepsin B inhibitor
|
Cathepsin B inhibitor RC1 is a small-molecule that blocks the process of anthrax lethal toxin (LT) cytotoxicity, inhibits enzymatic activity of host cathepsin B that mediates the escape of toxins into the cytoplasm from late endosomes. |
| PC-63161 |
AZD5248
DPP-1/CatC inhibitor
|
AZD5248 is a potent, selective, first generation, oral inhibitor of dipeptidyl peptidase 1 (DPP1, cathepsin C, CatC). |
| PC-62965 |
VEL-0230
Cathepsin inhibitor
|
VEL-0230 (NC-2300) is a potent, selective cysteine Cathepsins inhibitor with IC50 of 284, 34.5 and 186 nM for Cat B, K and S, respectively. |
| PC-62964 |
L 873724
Cathepsin K inhibitor
|
L 873724 is a potent and selective non-basic cathepsin K inhibitor with IC50 of 0.2 nM, shows no significant potency against Cat B, L, and S (IC50= 5239, 264, and 178 nM). |
| PC-62962 |
Relacatib
Cathepsin K inhibitor
|
Relacatib (SB-462795, GSK-462795) is a potent and orally bioavailable small molecule cathepsin inhibitor with Ki of 41, 68 and 53 pM for cathepsin K, L and V, respectively. |
| PC-62961 |
MK-0674
Cathepsin K inhibitor
|
MK-0674 (MK 0674) is a potent, selective, reversible and orally active cathepsin K inhibitor with IC50 of 1 nM. |
| PC-62813 |
KGP-94
Cathepsin L inhibitor
|
KGP-94 is a potent, selective cathepsin L inhibitor with IC50 of 189 nM, shows no significant inhibitory effect on cathepsin B (IC50>10 uM). |
| PC-62812 |
KGP-420
Cathepsin L inhibitor
|
KGP-420 is the water-soluble phosphate prodrug of KGP-94 in vivo studies, KGP-94 is a potent, selective cathepsin L inhibitor with IC50 of 189 nM. |
| PC-62811 |
LY-3000328
Cathepsin S inhibitor
|
LY-3000328 is a potent, highly selective cathepsin S inhibitor with IC50 of 7.7 nM. |
| PC-61421 |
ONO-5334
Cathepsin K inhibitor
|
ONO-5334 is a potent, selective, orally active inhibitor of cathepsin K with Ki of 0.1 nM, 0.049 nM and 0.85 nM for human, rabbit and rat cathepsin K, respectively. |
| PC-61355 |
GB111-NH2
Cathepsin inhibitor
|
GB111-NH2 (Z-Phe-Lys-AOMK) is a novel cysteine cathepsin inhibitor that blocks the activity of cathepsins B, L and S. |
| PC-60946 |
GSK 2793660
Cathepsin C inhibitor
|
GSK 2793660 (GSK2793660) is a potent, selective, irreversible and orally bioavailable cathepsin C (CTSC) inhibitor with IC50 of 0.43-1 nM. |
