LY-3000328 |CAS:1373215-15-6 Probechem Biochemicals

Chemical Structure : LY-3000328

CAS No.: 1373215-15-6

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LY-3000328 (LY3000328, LY 3000328, Z-FL-COCHO)

货号: PC-62811Not For Human Use, Lab Use Only.

LY-3000328 is a potent, highly selective cathepsin S inhibitor with IC50 of 7.7 nM.

规格	价格	库存
5 mg	￥1680	In stock
10 mg	￥2580	In stock
25 mg	￥4480	In stock
50 mg	￥7480	In stock
100 mg		Get quote

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生物&药学活性

LY-3000328 is a potent, highly selective cathepsin S inhibitor with IC50 of 7.7 nM.
LY-3000328 dispalys >500-fold selectivity over cathepsin L, cathepsint K, cathepsin B, and cathepsin V.
LY-3000328 shows efficacy in a CaCl2-induced AAA (Abdominal Aortic Aneurysm) in vivo model.

物理化学性质&存储条件

分子量	484.528
分子式	C25H29FN4O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3R,4S)-4-(4-fluorobenzamido)-6-(4-(oxetan-3-yl)piperazin-1-yl)chroman-3-yl methylcarbamate

参考文献

1. Jadhav PK, et al. ACS Med Chem Lett. 2014 Aug 27;5(10):1138-42.

2. Payne CD, et al. Br J Clin Pharmacol. 2014 Dec;78(6):1334-42.

3. Steimle A, et al. J Autoimmun. 2016 Dec;75:82-95.

LY-3000328 (LY3000328, LY 3000328, Z-FL-COCHO)

生物&药学活性

物理化学性质&存储条件

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LY-3000328 (LY3000328, LY 3000328, Z-FL-COCHO)

生物&药学活性

物理化学性质&存储条件

参考文献

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