L 873724 |CAS:603139-12-4 Probechem Biochemicals

Chemical Structure : L 873724

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L 873724 (L873724, L-873724)

货号: PC-62964Not For Human Use, Lab Use Only.

L 873724 is a potent and selective non-basic cathepsin K inhibitor with IC50 of 0.2 nM, shows no significant potency against Cat B, L, and S (IC50= 5239, 264, and 178 nM).

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生物&药学活性

L 873724 is a potent and selective non-basic cathepsin K inhibitor with IC50 of 0.2 nM, shows no significant potency against Cat B, L, and S (IC50= 5239, 264, and 178 nM).
L 873724 demonstrates excellent pharmacokinetics and efficacy in an ovariectomized (OVX) rhesus monkey model.

物理化学性质&存储条件

分子量	481.534
分子式	C23H26F3N3O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S)-N-(cyanomethyl)-4-methyl-2-[[(1S)-2,2,2-trifluoro-1-[4-(4-methylsulfonylphenyl)phenyl]ethyl]amino]pentanamide

参考文献

1. Li CS, et al. Bioorg Med Chem Lett. 2006 Apr 1;16(7):1985-9.

2. Desmarais S, et al. Mol Pharmacol. 2008 Jan;73(1):147-56.

3. Pennypacker BL, et al. BMC Musculoskelet Disord. 2013 Dec 9;14:344.

L 873724 (L873724, L-873724)

生物&药学活性

物理化学性质&存储条件

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L 873724 (L873724, L-873724)

生物&药学活性

物理化学性质&存储条件

参考文献

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