Cathepsin B inhibitor RC1 is a small-molecule that blocks the process of anthrax lethal toxin (LT) cytotoxicity, inhibits enzymatic activity of host cathepsin B that mediates the escape of toxins into the cytoplasm from late endosomes.
Cathepsin B inhibitor RC1 is a small-molecule that blocks the process of anthrax lethal toxin (LT) cytotoxicity, inhibits enzymatic activity of host cathepsin B that mediates the escape of toxins into the cytoplasm from late endosomes.
Cathepsin B inhibitor RC1 protects host cells independently of LT concentration and also blocks intoxication by other bacterial exotoxins.
Cathepsin B inhibitor RC1 reduces the pathogenicity of Human cytomegalovirus and HSV-1 (EC50=12 uM), which relies on cathepsin B protease activity.
