| Cat. No. |
Product Name |
Information |
| PC-24455 |
Brinzolamide
CA II inhibitor
|
Brinzolamide (AL-4862) is a potent, selective carbonic anhydrase II (CA II) inhibitor with IC50 of 3.2 nM, reduces intraocular pressure (IOP) by inhibiting ciliary CA-II and decreasing atrial fluid secretion. |
| PC-62314 |
Indisulam
Carbonic Anhydrase inhibitor
|
Indisulam (E7070) is potent, sulfonamide, carbonic anhydrase inhibitor that possesses antiproliferative activities, causes decrease in the S phase fraction along with G1 and/or G2 accumulation in various cancer cell lines. |
| PC-70028 |
SLC-0111
CA IX/CA XII inhibitor
|
SLC-0111 (U-104) is a sulfonamide carbonic anhydrase (CA, EC 4.2.1.1) inhibitor with IC50 of 45 nM and 4.5 nM for tumor-associated enzymes hCA IX and hCA XII. |
| PC-25822 |
PCI-27483
FVIIa inhibitor, hCA IX/hCA XII inhibitor
|
PCI-27483 is a potent and selective inhibitor of the serine protease Factor VIIa (FVIIa) in complex with tissue factor (TF), also inhibits human carbonic anhydrase IX and XII (hCA IX and XII) with IC50 of 35.7 nM and 4.7 nM, also is a potential Transmembrane protease, serine 2 (TMPRSS2) inhibitor (IC50=1.41 uM) for antiviral of SARS-CoV-2. |
| PC-25270 |
FC-531
Carbonic anhydrase inhibitor
|
FC-531 is a highly potent carbonic anhydrase (CA) inhibitor with Ki values of 6.2 nM and 2.3 nM for the transmembrane and tumor-associated isoforms CA IX and CA XII. |
| PC-24459 |
Dichlorophenamide
Carbonic anhydrase inhibitor
|
Dichlorophenamide is a potent carbonic anhydrase inhibitor with Ki values of 1200, 38, 1500, 50 and 50 nM for isozymes hCA I, hCA II, hCA IV, hCA IX, and hCA XII respectively. |
| PC-24458 |
Ethoxzolamide
Carbonic anhydrase inhibitor
|
Ethoxzolamide is a potent carbonic anhydrase inhibitor with Ki values of 25, 8, 93, 34 and 22 nM for isozymes hCA I, hCA II, hCA IV, hCA IX, and hCA XII respectively. |
| PC-24457 |
Methazolamide
CA II inhibitor
|
Methazolamide (L584601) is a potent, BBB-penatrable and orally active carbonic anhydrase inhibitor with Ki of 14 nM for human carbonic anhydrase II (CA II). |
| PC-24456 |
Dorzolamide hydrochloride
CA II inhibitor
|
Dorzolamide hydrochloride (L671152) is a potent, selective carbonic anhydrase II (CA II) inhibitor with IC50 values of 0.18 nM and 600 nM for red blood cell CA-II and CA-I respectively. |
| PC-24454 |
Carbonic anhydrase inhibitor C18
CAS 215998-88-2
|
Carbonic anhydrase inhibitor C18 is a potent carbonic anhydrase inhibitor with Ki values of 4000, 21, 60, 14 and 7.0 nM for isozymes hCA I, hCA II, hCA IV, hCA IX, and hCA XII respectively. |
| PC-23741 |
VD11-4-2
CA IX inhibitor
|
VD11-4-2 is a high affinity, selectivity inhibitor of carbonic anhydrase IX (CA IX) with ITC Kd of 15 pM, with remarkable selectivity over other CA isozymes. |
| PC-23740 |
AZ19-3-1
CA IX inhibitor
|
AZ19-3-2 is a high affinity, selective inhibitor of carbonic anhydrase IX (CA IX) with binding Kd of 250 pM in thermal shift assays. |
