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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Carbonic Anhydrase-PCI-27483
PCI-27483

Chemical Structure : PCI-27483

CAS No.:

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PCI-27483 (PCI 27483)

货号: PC-25822Not For Human Use, Lab Use Only.

PCI-27483 is a potent and selective inhibitor of the serine protease Factor VIIa (FVIIa) in complex with tissue factor (TF), also inhibits human carbonic anhydrase IX and XII (hCA IX and XII) with IC50 of 35.7 nM and 4.7 nM, also is a potential Transmembrane protease, serine 2 (TMPRSS2) inhibitor (IC50=1.41 uM) for antiviral of SARS-CoV-2.

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5 mg ￥1280 In stock
10 mg ￥1980 In stock
25 mg ￥3580 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

PCI-27483 is a potent and selective inhibitor of the serine protease Factor VIIa (FVIIa) in complex with tissue factor (TF), also inhibits human carbonic anhydrase IX and XII (hCA IX and XII) with IC50 of 35.7 nM and 4.7 nM, also is a potential Transmembrane protease, serine 2 (TMPRSS2) inhibitor (IC50=1.41 uM) for antiviral of SARS-CoV-2.

物理化学性质&存储条件

分子量 596.57
分子式 C26H24N6O9S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(2-(5-(6-Carbamimidoyl-1H-benzo[d]imidazol-2-yl)-2',6-dihydroxy-5'-sulfamoyl-[1,1'-biphenyl]-3-yl)acetyl)-L-aspartic acid

参考文献

1. D'Agostino I, et al. ACS Med Chem Lett. 2024 Oct 21;15(11):2042-2045.

2. Ramanathan RK, et al. Oncology. 2019;96(4):217-222.

3. Shrimp JH, et al. ACS Infect Dis. 2022 Jun 10;8(6):1191-1203.

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