FC-531 | Carbonic anhydrase inhibitor | Probechem Biochemicals

Chemical Structure : FC-531

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FC-531 (FC531)

货号: PC-25270Not For Human Use, Lab Use Only.

FC-531 is a highly potent carbonic anhydrase (CA) inhibitor with Ki values of 6.2 nM and 2.3 nM for the transmembrane and tumor-associated isoforms CA IX and CA XII.

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生物&药学活性

FC-531 is a highly potent carbonic anhydrase (CA) inhibitor with Ki values of 6.2 nM and 2.3 nM for the transmembrane and tumor-associated isoforms CA IX and CA XII.
FC-531 shows remarkable efficacy in inhibiting the hCA I isoform with Ki of 9.4 nM, has limited affinity for hCA II (Ki >1000 nM).
FC-531 significantly triggers apoptotic cell death on prototypic triple negative breast cancer (TNBC) and melanoma cells.
FC-531 displays a higher anti-tumor effect in comparison with SLC-0111.
FC-531 (50 mg/kg) reduces tumor growth and metastatization in NOD/SCID mice to obtain lung metastasis.

物理化学性质&存储条件

分子量	359.32
分子式	C14H12F3N3O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(3-(4-(trifluoromethyl)phenyl)ureido)benzenesulfonamide

参考文献

1. Pacchiano F, et al. J Med Chem. 2011;54:1896–902.

2. Gazzaroli G, et al. Exp Hematol Oncol. 2025 Aug 8;14(1):104.

FC-531 (FC531)

生物&药学活性

物理化学性质&存储条件

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FC-531 (FC531)

生物&药学活性

物理化学性质&存储条件

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