VD11-4-2

Chemical Structure : VD11-4-2

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货号: PC-23741Not For Human Use, Lab Use Only.

VD11-4-2 is a high affinity, selectivity inhibitor of carbonic anhydrase IX (CA IX) with ITC Kd of 15 pM, with remarkable selectivity over other CA isozymes.

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生物&药学活性

VD11-4-2 is a high affinity, selectivity inhibitor of carbonic anhydrase IX (CA IX) with ITC Kd of 15 pM, with remarkable selectivity over other CA isozymes.
VD11-4-2 exhibits strongest inhibition of recombinant human CA IX's catalytic domain in human cells achieved an affinity of 50 pM.

物理化学性质&存储条件

分子量	444.48
分子式	C16H23F3N2O5S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(cyclooctylamino)-2,5,6-trifluoro-4-((2-hydroxyethyl)sulfonyl)benzenesulfonamide

参考文献

1. Kazokaitė J, et al. J Enzyme Inhib Med Chem. 2016;31(sup4):38-44.

2. Dudutienė, V. et al. Journal of Medicinal Chemistry, 57, 9435–9446.

VD11-4-2

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物理化学性质&存储条件

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VD11-4-2

生物&药学活性

物理化学性质&存储条件

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