| Cat. No. |
Product Name |
Information |
| PC-62766 |
AZD8329
11β-HSD1 inhibitor
|
AZD8329 (AZD-8329) is a potent, selective 11β-HSD1 inhibitor with IC50 of 9 nM, displays excellent selectivity versus relatedd 11β-HSD2, 17β-HSD1 and 17β-HSD3 (IC50>30 uM). |
| PC-61987 |
AZD4017
11β-HSD1 inhibitor
|
AZD4017 (AZD-4017) is a potent, selective, and orally bioavailable human 11β-HSD1 with IC50 of 7 nM, shows no significant activity against 11β-HSD1 and 17β-HSD1, 17β-HSD3 (IC50>30 uM). |
| PC-61492 |
BMS-823778
11β-HSD1 inhibitor
|
BMS-823778 (BMS823778) is an orally available, potent and selective inhibitor of 11βHSD-1 with IC50 of 2.3 nM, displays >10,000-fold selectivity over 11βHSD-2. |
| PC-61137 |
SKI2852
11β-HSD1 inhibitor
|
SKI-2852 (J2H-1702) is a highly potent, selective, and orally bioavailable 11β-HSD1 inhibitor with IC50 of 2.9 and 1.6 nM for hHSD1 and mHSD1, respectively. |
| PC-60448 |
BI 135585
11β-HSD1 inhibitor
|
BI 135585 (BI-135585, BI135585) is a potent, selective, orally active 11β-HSD1 inhibitor with IC50 of 4.3 nM and 53 nM in human adipocytes and primary human adipose tissue, respectively. |
| PC-60371 |
UE2343
11β-HSD1 inhibitor
|
UE2343 (Emestedastat, UE-2343, Xanamem) is a potent, orally bioavailable, brain penetrant 11β-HSD1 inhibitor with IC50 of 24 nM in cell-free assays, with no activity for isozyme 11β-HSD2. |
| PC-60349 |
BMS-816336
11β-HSD1 inhibitor
|
BMS-816336 is a novel potent, selective, orally active human 11β-HSD1 inhibitor with IC50 of 3.0 nM. |
| PC-60344 |
Carbenoxolone
11β-HSD inhibitor
|
Carbenoxolone (YP003, YP-003) is a glycyrrhetinic acid derivative that inhibits 11β-hydroxysteroid dehydrogenase (11β-HSD), a gap junction blocker and mineralocorticoid agonist. |
| PC-60343 |
Carbenoxolone disodium
11β-HSD inhibitor
|
Carbenoxolone disodium is a glycyrrhetinic acid derivative that inhibits 11β-hydroxysteroid dehydrogenase (11β-HSD), a gap junction blocker and mineralocorticoid agonist. |
| PC-45408 |
PF-915275
11β-HSD1 inhibitor
|
PF-915275 is a specific and potent inhibitor of the human11β-HSD1 with Ki of 2.3 nM and in vitro HEK293 EC50 of 15 nM, with minimal inhibitory activity toward the mouse enzyme (Ki=750 nM). |
| PC-45407 |
BVT-14225
11β-HSD1 inhibitor
|
BVT-14225 is a selective 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor with IC50 of 52 nM. |
| PC-45406 |
BVT2733
11β-HSD1 inhibitor
|
BVT2733 (BVT-2733, BVT.2733) is a non-steroidal, isoform-selective inhibitor of mouse 11β-HSD1 with Ki of 1 uM. |
