| Cat. No. |
Product Name |
Information |
| PC-60371 |
UE2343
11β-HSD1 inhibitor
|
UE2343 (Emestedastat, UE-2343, Xanamem) is a potent, orally bioavailable, brain penetrant 11β-HSD1 inhibitor with IC50 of 24 nM in cell-free assays, with no activity for isozyme 11β-HSD2. |
| PC-60349 |
BMS-816336
11β-HSD1 inhibitor
|
BMS-816336 is a novel potent, selective, orally active human 11β-HSD1 inhibitor with IC50 of 3.0 nM. |
| PC-60344 |
Carbenoxolone
11β-HSD inhibitor
|
Carbenoxolone is a glycyrrhetinic acid derivative that inhibits 11β-hydroxysteroid dehydrogenase (11β-HSD), a gap junction blocker and mineralocorticoid agonist. |
| PC-60343 |
Carbenoxolone disodium
11β-HSD inhibitor
|
Carbenoxolone disodium is a glycyrrhetinic acid derivative that inhibits 11β-hydroxysteroid dehydrogenase (11β-HSD), a gap junction blocker and mineralocorticoid agonist. |
| PC-45408 |
PF-915275
11β-HSD1 inhibitor
|
PF-915275 is a specific and potent inhibitor of the human11β-HSD1 with Ki of 2.3 nM and in vitro HEK293 EC50 of 15 nM, with minimal inhibitory activity toward the mouse enzyme (Ki=750 nM). |
| PC-45407 |
BVT-14225
11β-HSD1 inhibitor
|
BVT-14225 is a selective 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor with IC50 of 52 nM. |
| PC-45406 |
BVT-2733
11β-HSD1 inhibitor
|
BVT-2733 (BVT2733) is a non-steroidal, isoform-selective inhibitor of mouse 11β-HSD1 with Ki of 1 uM. |
| PC-24917 |
ESC1002755
17β-HSD10 inhibitor
|
ESC1002755 is a highly potent 17β-Hydroxysteroid type 10 (17β-HSD10) inhibitor with IC50 of 19 nM in biochemical assays, inhibits cellular 17β-HSD10 activity with EC50 of 28 nM in stable HEK 293 cell line overexpressing 17β-HSD10. |
| PC-24810 |
HEAL-116
3βHSD1 inhibitor
|
HEAL-116 is a potent, selective 3β-hydroxysteroid dehydrogenase type 1 (3βHSD1) inhibitor, shows binding specificity to the substrate-binding pocket of 3βHSD1 and effectively neutralizes the local charge environment. |
| PC-24097 |
Emodin
11β-HSD1 inhibitor, Nrf2 activator
|
Emodin (Frangula emodin) is an anthraquinone derivative with anti-SARS-CoV activity, blocks the SARS coronavirus spike protein and ACE2 interaction, also inhibits casein kinase-2 (CK2), also activates Nrf2 and effectively targets PD pathology. |
| PC-21934 |
MK-0736
11β-HSD1 inhibitor
|
MK-0736 is a potent, selective 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor, shows favourable effect on glucose and lipid metabolism, weight reduction and adipokine levels. |
| PC-20841 |
AMG221
11beta-HSD1 inhibitor
|
AMG221 is a potent, selective orally active 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) inhibitor with Ki of 12.8 nM and cell IC50 of 10.1 nM. |
