BI 135585 |CAS:1114561-85-1 Probechem Biochemicals

Chemical Structure : BI 135585

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BI 135585 (BI-135585;BI135585)

货号: PC-60448Not For Human Use, Lab Use Only.

BI 135585 (BI-135585, BI135585) is a potent, selective, orally active 11β-HSD1 inhibitor with IC50 of 4.3 nM and 53 nM in human adipocytes and primary human adipose tissue, respectively.

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生物&药学活性

BI 135585 (BI-135585, BI135585) is a potent, selective, orally active 11β-HSD1 inhibitor with IC50 of 4.3 nM and 53 nM in human adipocytes and primary human adipose tissue, respectively.
BI 135585 exhibits >1,000-fold selectivity over other hydroxysteroid dehydrogenases.
BI 135585 inhibits 11β HSD1 activity in adipose tissue, displays desirable pharmacodynamic properties in vivo.

物理化学性质&存储条件

分子量	460.574
分子式	C28H32N2O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-6-(2-hydroxy-2-methylpropyl)-3-((S)-1-(4-(1-methyl-2-oxo-1,2-dihydropyridin-4-yl)phenyl)ethyl)-6-phenyl-1,3-oxazinan-2-one

参考文献

1. Hamilton BS, et al. Eur J Pharmacol. 2015 Jan 5;746:50-5.

2. Freude S, et al. Diabetes Obes Metab. 2016 May;18(5):483-90.

3. Zhuang L, et al. Bioorg Med Chem. 2017 Jul 15;25(14):3649-3657.

4. Hamilton BS, et al. Eur J Pharmacol. 2016 Oct 15;789:68-74.

BI 135585 (BI-135585;BI135585)

生物&药学活性

物理化学性质&存储条件

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BI 135585 (BI-135585;BI135585)

生物&药学活性

物理化学性质&存储条件

参考文献

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