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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-11β-HSD-UE2343
UE2343

Chemical Structure : UE2343

CAS No.: 1346013-80-6

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UE2343 (Emestedastat, UE-2343, Xanamem)

货号: PC-60371Not For Human Use, Lab Use Only.

UE2343 (Emestedastat, UE-2343, Xanamem) is a potent, orally bioavailable, brain penetrant 11β-HSD1 inhibitor with IC50 of 24 nM in cell-free assays, with no activity for isozyme 11β-HSD2.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    UE2343 (Emestedastat, UE-2343, Xanamem) is a potent, orally bioavailable, brain penetrant 11β-HSD1 inhibitor with IC50 of 24 nM in cell-free assays, with no activity for isozyme 11β-HSD2.
    UE2343 (UE-2343, Xanamem) displays a superior preclinical profile for further development, and shows potential for cognitive impairment in early Alzheimer's disease (AD).

    物理化学性质&存储条件

    分子量 381.454
    分子式 C19H19N5O2S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (5-(1H-pyrazol-4-yl)thiophen-3-yl)((1R,3r,5S)-3-hydroxy-3-(pyrimidin-2-yl)-8-azabicyclo[3.2.1]octan-8-yl)methanone

    参考文献

    1. Webster SP, et al. Br J Pharmacol. 2017 Mar;174(5):396-408.

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