BMS-816336 |CAS:1009583-20-3 Probechem Biochemicals

Chemical Structure : BMS-816336

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BMS-816336 (BMS 816336;BMS816336)

货号: PC-60349Not For Human Use, Lab Use Only.

BMS-816336 is a novel potent, selective, orally active human 11β-HSD1 inhibitor with IC50 of 3.0 nM.

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生物&药学活性

BMS-816336 is a novel potent, selective, orally active human 11β-HSD1 inhibitor with IC50 of 3.0 nM.
BMS-816336 displays >10,000-fold selectivity over huma 11β-HSD2.
BMS-816336 exhibits a robust acute pharmacodynamic effect in cynomolgus monkeys (ED50=0.12 mg/kg) and in DIO mice.

物理化学性质&存储条件

分子量	341.451
分子式	C21H27NO3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((1R,2R,3S,5R,6R)-6-hydroxy-2-phenyladamantan-2-yl)-1-(3-hydroxyazetidin-1-yl)ethan-1-one

参考文献

1. Ye XY, et al. J Med Chem. 2017 Jun 22;60(12):4932-4948.

2. Maxwell BD. J Labelled Comp Radiopharm. 2017 Jun 30;60(8):357-365.

BMS-816336 (BMS 816336;BMS816336)

生物&药学活性

物理化学性质&存储条件

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BMS-816336 (BMS 816336;BMS816336)

生物&药学活性

物理化学性质&存储条件

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