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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-11β-HSD-BVT-14225
BVT-14225

Chemical Structure : BVT-14225

CAS No.: 376638-65-2

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BVT-14225 (BVT14225, BVT 14225)

货号: PC-45407Not For Human Use, Lab Use Only.

BVT-14225 is a selective 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor with IC50 of 52 nM.

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5 mg ￥880 In stock
10 mg ￥1280 In stock
25 mg ￥2180 In stock
50 mg ￥3580 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

BVT-14225 is a selective 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor with IC50 of 52 nM.
BVT-14225 displays >200-fold selectivity over human and murine 11β-HSD2.
BVT-14225 reduces glucose levels in diabetic KKA(y) mice.

物理化学性质&存储条件

分子量 401.9313
分子式 C16H20ClN3O3S2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 27 mg/mL
Chemical Name/SMILES

4-Thiazoleacetamide, 2-[[(3-chloro-2-methylphenyl)sulfonyl]amino]-N,N-diethyl-

参考文献

1. Barf T, et al. J Med Chem. 2002 Aug 29;45(18):3813-5.

2. Vicker N, et al. J Steroid Biochem Mol Biol. 2007 May;104(3-5):123-9.

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