| Cat. No. |
Product Name |
Information |
| PC-21320 |
TPT-004
TPH inhibitor
|
TPT-004 is a highly potent, selective tryptophan hydroxylase (TPH) with IC50 of 77 nM and 16 nM for TPH1 and TPH2, respectively. |
| PC-43357 |
Telotristat
TPH inhibitor
|
Telotristat (LP-778902) is a potent, small-molecule inhibitor of peripheral serotonin synthesis, acts by inhibiting tryptophan hydroxylase (TPH) with IC50 of 28 nM. |
| PC-43356 |
LX1606
TPH inhibitor
|
LX1606 (Telotristat ethyl) is a potent, small-molecule inhibitor of peripheral serotonin synthesis, acts by inhibiting tryptophan hydroxylase (TPH) with IC50 of 28 nM, demonstrates potential for the treatment of carcinoid syndrome.. |
| PC-43355 |
Telotristat etiprate
TPH inhibitor
|
Telotristat etiprate (LX1606 hippurate) is an orally active, small-molecule inhibitor of peripheral serotonin synthesis, acts by inhibiting tryptophan hydroxylase (TPH) with IC50 of 28 nM, demonstrates potential for the treatment of carcinoid syndrome. |
| PC-43351 |
LX-1031
TPH inhibitor
|
LX-1031 is a potent, orally active tryptophan 5-hydroxylase (TPH) inhibitor with potency of 10-100 nM, reduces 5-HT synthesis peripherally. |
| PC-62808 |
KAR5585
TPH1 inhibitor
|
KAR5585 (Rodatristat ethyl) is the prodrug of the potent TPH1 inhibitor KAR5417, shows robust reduction of intestinal serotonin (5-HT) levels in mice. |
| PC-62807 |
KAR5417
TPH1 inhibitor
|
Rodatristat (KAR5417) is a potent, selective TPH1 (tryptophan hydroxylase-1) inhibitor with IC50 of 33 nM. |
