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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Tryptophan Hydroxylase (TPH)-LP-533401
LP-533401

Chemical Structure : LP-533401

CAS No.: 945976-43-2

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LP-533401 (LP533401)

货号: PC-28323Not For Human Use, Lab Use Only.

LP-533401 (LP533401) is a potent, peripheral Tryptophan hydroxylase 1 (TPH1) inhibitor, inhibits the rate-limiting step of serotonin (5-HT) synthesis, selectively reduce 5-HT levels in the murine gastrointestinal tract without affecting brain 5-HT levels.

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5 mg ￥780 In stock
10 mg ￥1180 In stock
25 mg ￥1980 In stock
50 mg ￥2980 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

LP-533401 (LP533401) is a potent, peripheral Tryptophan hydroxylase 1 (TPH1) inhibitor, inhibits the rate-limiting step of serotonin (5-HT) synthesis, selectively reduce 5-HT levels in the murine gastrointestinal tract without affecting brain 5-HT levels.

物理化学性质&存储条件

分子量 526.49
分子式 C27H22F4N4O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(2S)-2-Amino-3-(4-(2-amino-6-(2,2,2-trifluoro-1-(3'-fluoro-[1,1'-biphenyl]-4-yl)ethoxy)pyrimidin-4-yl)phenyl)propanoic acid

参考文献

1. Namkung J, et al. Diabetes Metab J. 2018 Jun;42(3):233-243.

2. Liu Q, et al. J Pharmacol Exp Ther. 2008;325:47–55.

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