Telotristat (LP-778902) | TPH inhibitor | Probechem Biochemicals

Chemical Structure : Telotristat

CAS No.: 1033805-28-5

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Telotristat (LP778902, LP 778902, LP-778902)

货号: PC-43357Not For Human Use, Lab Use Only.

Telotristat (LP-778902) is a potent, small-molecule inhibitor of peripheral serotonin synthesis, acts by inhibiting tryptophan hydroxylase (TPH) with IC50 of 28 nM.

规格	价格	库存
5 mg	￥880	In stock
10 mg	￥1280	In stock
25 mg	￥2180	In stock
50 mg	￥3580	In stock
100 mg	￥5480	In stock
250 mg		Get quote

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生物&药学活性

Telotristat (LP-778902) is a potent, small-molecule inhibitor of peripheral serotonin synthesis, acts by inhibiting tryptophan hydroxylase (TPH) with IC50 of 28 nM.
Telotristat (LP-778902) demonstrates potential for the treatment of carcinoid syndrome.

物理化学性质&存储条件

分子量	546.9288
分子式	C25H22ClF3N6O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	L-Phenylalanine, 4-[2-amino-6-[(1R)-1-[4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]-4-pyrimidinyl]-

参考文献

1. Margolis KG, et al. Gut. 2014 Jun;63(6):928-37.

2. Kulke MH, et al. Endocr Relat Cancer. 2014 Oct;21(5):705-14.

3. Kulke MH, et al. J Clin Oncol. 2017 Jan;35(1):14-23.

4. Kim JJ, et al. Am J Physiol Gastrointest Liver Physiol.

Telotristat (LP778902, LP 778902, LP-778902)

生物&药学活性

物理化学性质&存储条件

参考文献

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Telotristat (LP778902, LP 778902, LP-778902)

生物&药学活性

物理化学性质&存储条件

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