TPT-004 | TPH inhibitor | Probechem Biochemicals

Chemical Structure : TPT-004

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TPT-004 (TPT004)

货号: PC-21320Not For Human Use, Lab Use Only.

TPT-004 is a highly potent, selective tryptophan hydroxylase (TPH) with IC50 of 77 nM and 16 nM for TPH1 and TPH2, respectively.

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生物&药学活性

TPT-004 is a highly potent, selective tryptophan hydroxylase (TPH) with IC50 of 77 nM and 16 nM for TPH1 and TPH2, respectively.
TPT-004 displays no relevant impact at 20 μM on the function of the LAT1 transporter involved in the transport of tryptophan, phenylalanine, leucine, and histidine to the brain.
TPT-004 reduced the intracellular serotonin levels with IC50 of 0.952 uM in serotonergic BON cells, a human carcinoid cell line known to express TPH1.
TPT-004 showed efficacy in preclinical models of peripheral serotonin attenuation and colorectal tumor growth.

物理化学性质&存储条件

分子量	400.46
分子式	C18H20N6O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-Ethyl-8-((2-methylimidazo[2,1-b]thiazol-6-yl)methyl)-7-(oxetan-3-ylmethyl)-3,7-dihydro-1H-purine-2,6-dione

参考文献

1. Edgar Specker, et al. J Med Chem. 2023 Nov 9;66(21):14866-14896.

TPT-004 (TPT004)

生物&药学活性

物理化学性质&存储条件

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TPT-004 (TPT004)

生物&药学活性

物理化学性质&存储条件

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