Telotristat etiprate (LX1606) | TPH inhibitor | Probechem Biochemicals

Chemical Structure : Telotristat etiprate

CAS No.: 1137608-69-5

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Telotristat etiprate (LX1606 Hippurate)

货号: PC-43355Not For Human Use, Lab Use Only.

Telotristat etiprate (LX1606 hippurate) is an orally active, small-molecule inhibitor of peripheral serotonin synthesis, acts by inhibiting tryptophan hydroxylase (TPH) with IC50 of 28 nM, demonstrates potential for the treatment of carcinoid syndrome.

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5 mg	￥880	In stock
10 mg	￥1280	In stock
25 mg	￥2180	In stock
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100 mg		Get quote

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Telotristat etiprate (LX1606 hippurate) is an orally active, small-molecule inhibitor of peripheral serotonin synthesis, acts by inhibiting tryptophan hydroxylase (TPH) with IC50 of 28 nM, demonstrates potential for the treatment of carcinoid syndrome.

物理化学性质&存储条件

分子量	754.1546
分子式	C36H35ClF3N7O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 28 mg/mL
Chemical Name/SMILES	L-Phenylalanine, 4-[2-amino-6-[(1R)-1-[4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]-4-pyrimidinyl]-, ethyl ester, compd. with N-benzoylglycine (1:1)

参考文献

1. Margolis KG, et al. Gut. 2014 Jun;63(6):928-37.

2. Kulke MH, et al. Endocr Relat Cancer. 2014 Oct;21(5):705-14.

3. Kulke MH, et al. J Clin Oncol. 2017 Jan;35(1):14-23.

4. Kim JJ, et al. Am J Physiol Gastrointest Liver Physiol.

Telotristat etiprate (LX1606 Hippurate)

生物&药学活性

物理化学性质&存储条件

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Telotristat etiprate (LX1606 Hippurate)

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