| Cat. No. |
Product Name |
Information |
| PC-28323 |
LP-533401
Tryptophan hydroxylase inhibitor
|
LP-533401 (LP533401) is a potent, peripheral Tryptophan hydroxylase 1 (TPH1) inhibitor, inhibits the rate-limiting step of serotonin (5-HT) synthesis, selectively reduce 5-HT levels in the murine gastrointestinal tract without affecting brain 5-HT levels. |
| PC-21320 |
TPT-004
TPH inhibitor
|
TPT-004 is a highly potent, selective tryptophan hydroxylase (TPH) with IC50 of 77 nM and 16 nM for TPH1 and TPH2, respectively. |
| PC-43357 |
Telotristat
TPH inhibitor
|
Telotristat (LP-778902) is a potent, small-molecule inhibitor of peripheral serotonin synthesis, acts by inhibiting tryptophan hydroxylase (TPH) with IC50 of 28 nM. |
| PC-43356 |
LX1606
TPH inhibitor
|
Telotristat ethyl (LX1606) is a potent, small-molecule inhibitor of peripheral serotonin synthesis, acts by inhibiting tryptophan hydroxylase (TPH) with IC50 of 28 nM. |
| PC-43355 |
Telotristat etiprate
TPH inhibitor
|
Telotristat etiprate (LX1606 hippurate) is an orally active, small-molecule inhibitor of peripheral serotonin synthesis, acts by inhibiting tryptophan hydroxylase (TPH) with IC50 of 28 nM, demonstrates potential for the treatment of carcinoid syndrome. |
| PC-43351 |
LX-1031
TPH inhibitor
|
LX-1031 is a potent, orally active tryptophan 5-hydroxylase (TPH) inhibitor with potency of 10-100 nM, reduces 5-HT synthesis peripherally. |
| PC-62808 |
Rodatristat ethyl
TPH1 inhibitor
|
Rodatristat ethyl (KAR5585) is the prodrug of the potent TPH1 inhibitor KAR5417, shows robust reduction of intestinal serotonin (5-HT) levels in mice. |
| PC-62807 |
Rodatristat
TPH1 inhibitor
|
Rodatristat (KAR5417) is a potent, selective TPH1 (tryptophan hydroxylase-1) inhibitor with IC50 of 33 nM. |
| PC-28322 |
Fenclonine
Tryptophan hydroxylase inhibitor
|
Fenclonine (PCPA) is a reversible, blood brain barrier permeable tryptophan hydroxylase (TPH) inhibitor, inhibits serotonin (5-HT) synthesis, reduces 5-HT central availability. |
| PC-28321 |
PCPA methyl ester hydrochloride
Tryptophan hydroxylase inhibitor
|
PCPA methyl ester hydrochloride is a reversible, blood brain barrier permeable tryptophan hydroxylase (TPH) inhibitor, inhibits serotonin (5-HT) synthesis, reduces 5-HT central availability. |
| PC-28320 |
TPH1-IN-1
TPH1 inhibitor
|
TPH1-IN-1 is a potent small molecule inhibitor of Tryptophan hydroxylase 1 (TPH1) with IC50 of 110.1 nM, effectively suppresses the adipocyte differentiation of 3 T3-L1 cells. |
