| Cat. No. |
Product Name |
Information |
| PC-22083 |
PCC0208057
TRPC6 inhibitor
|
PCC0208057 is a potent, selective TRPC6 channel inhibitor, inhibits TRPC6-mediated Ca2+ concentration increase with IC50 of 2.44 uM, binds directly to TRPC6. |
| PC-21908 |
GDC-6599
TRPA1 antagonist
|
Nedizantrep (GDC-6599) is a potent, selective transient receptor potential ankyrin 1 (TRPA1) antagonist with IC50 of 5.3 nM (hTRPA1), exhibits TRPA1 cell potency (IC50=20 nM) in the Ca2+ influx assay in CHO cells. |
| PC-21579 |
HC-030031
TRPA1 inhibitor
|
HC-030031 is a potent, selective TRPA1 inhibitor, inhibits AITC- and formalin-evoked calcium influx with IC50s of 6.2 and 5.3 μM, respectively. |
| PC-21344 |
M085
TRPC3/6/7 activator
|
M085 (TRPC3/6/7 activator 4o) is a potent and selective TRPC3/6/7 activator with EC50 of 4.66 uM, also activates hTRPC6 with EC50 of 3.8 uM. |
| PC-21131 |
AAL-149
TRPM7 inhibitor
|
AAL-149 is a non-phosphorylatable FTY720 analogue and novel TRPM7 inhibitor, inhibits IM7 in a dose-dependent manner with IC50 of 1.081 uM, shows potent anti-inflammatory effects in vivo. |
| PC-21130 |
VPC01091.4
TRPM7 inhibitor
|
VPC01091.4 is a non-phosphorylatable FTY720 analogue and novel TRPM7 inhibitor, inhibits IM7 in a dose-dependent manner with IC50 of 0.665 uM. |
| PC-21060 |
MK6-83
TRPML1 agonist
|
MK6-83 is a specific transient receptor potential mucolipin -1 (TRPML1/MCOLN1) agonist, activates the entire endosomal TRPML1 current in DMD myocytes with EC50 of 285 nM. |
| PC-20875 |
TRPV2 inhibitor IV2-1
TRPV2 inhibitor
|
TRPV2 inhibitor IV2-1 is a novel TRPV2-selective blocker, inhibits 2-APB elicited typical inwardly rectifying TRPV2 currents with IC50 of 0.8 uM. |
| PC-20743 |
SAR7334
TRPC6 inhibitor
|
SAR7334 (SAR-7334) is a highly potent and selective inhibitor of TRPC6 channel, reduces TRPC6-mediated Ca2+ influx with IC50 of 9.5 nM. |
| PC-20552 |
GsMTx4
TRPC1/6 inhibitor, Piezo channel inhibitor
|
GsMTx4 is a spider venom peptide that selectively inhibits cationic mechanosensitive channels (MSCs) such as TRPC1 and TRPC6 and Piezo channels, also blocks cation-selective stretch-activated channels (SACs). |
| PC-20367 |
TRPM5 inhibitor NDNA
TRPM5 inhibitor
|
TRPM5 inhibitor NDNA is potent and selecive TRPM5 inhibitor, inhibits Ca2+- induced TRPM5 currents with IC50 of 2.4 nM. |
| PC-20366 |
Triphenylphosphine oxide
TRPM5 inhibitor
|
Triphenylphosphine oxide (TPPO) is a selective and potent inhibitor of TRPM5 with IC50 of 12 and 30 uM for human and murine TRPM5 heterologously expressed in HEK293 cells. |
