JD03-02

Chemical Structure : JD03-02

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货号: PC-26845Not For Human Use, Lab Use Only.

JD03-02 is a potent, highly selective small-molecule inhibitor of TRPC1/5 heteromers with IC50 of 0.2 nM, exhibiting >10,000-fold selectivity for TRPC1/5 heteromers over TRPC5 homomers.

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生物&药学活性

JD03-02 is a potent, highly selective small-molecule inhibitor of TRPC1/5 heteromers with IC50 of 0.2 nM, exhibiting >10,000-fold selectivity for TRPC1/5 heteromers over TRPC5 homomers.
JD03-02 also selectively inhibits TRPC1/4 heteromers over TRPC4 homomers (IC50 = 6.7 nM vs. 2385 nM).
JD03-02 exhibits minimal activity against other closely related TRPC family members, including TRPC3, TRPC6, and TRPC7 (all IC50 >10 uM).
JD03-02 (10 mg/kg and 30 mg/kg) exhibits rapid and robust antidepressant and anxiolytic efficacy in rodent models, does not induce
hyperphagia or locomotor hyperactivity.

物理化学性质&存储条件

分子量	516.42
分子式	C25H27Cl2N5O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	7-(4-chlorobenzyl)-8-(3-chlorophenoxy)-1-(4-(dimethylamino)butyl)-3-methyl-3,7-dihydro-1H-purine-2,6-dione

参考文献

1. Chen Y, et al. Nat Commun. 2026 May 23. doi: 10.1038/s41467-026-73409-1.

JD03-02

生物&药学活性

物理化学性质&存储条件

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JD03-02

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