VU0619195 | Ordered membrane domains inhibitor | Probechem Biochemicals

Chemical Structure : VU0619195

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VU0619195 (VU 0619195, VU-0619195)

货号: PC-27130Not For Human Use, Lab Use Only.

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200 mg		Get quote

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生物&药学活性

VU0619195 is a small molecule disruptor of ordered membrane domains in cells, destabilize raft formation and decrease protein partitioning reduced the raft affinities of both PMP22 and MAL with EC50 of 1.62 uM and 1.37 uM.
VU0619195 alters membrane fluidity in vesicles and live cells.
VU0619195 reduces TRPM8 activation in response to menthol stimulation in TRPM8 HEK293T cells.
VU0619195 inhibits activation of KCNQ1/KCNE1.
VU0619195 reduces raft stability through a mechanism that involves both direct interactions with proteins and the disruption of lipid packing.

物理化学性质&存储条件

分子量	327.77
分子式	C16H14ClN5O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(5-chloro-2-methylphenyl)-5-(phenylamino)-1H-1,2,3-triazole-4-carboxamide

参考文献

1. Katherine M Stefanski, et al. Proc Natl Acad Sci U S A. 2026 Jun 30;123(26):e2530579123.

VU0619195 (VU 0619195, VU-0619195)

生物&药学活性

物理化学性质&存储条件

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VU0619195 (VU 0619195, VU-0619195)

生物&药学活性

物理化学性质&存储条件

参考文献

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