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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-TRP Channel-Z3571
Z3571

Chemical Structure : Z3571

CAS No.: 68724-80-1

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Z3571 (Z-3571)

货号: PC-25774Not For Human Use, Lab Use Only.

Z3571 is a potent, highly selective and orally bioavailable TRPC6 inhibitor with binding KD of 1.62 uM, inhibits OAG-stimulated Ca2+ influx with IC50 of 31.07 nM, shows >100-fold selectivity over TRPC3 and TRPC7.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    Z3571 is a potent, highly selective and orally bioavailable TRPC6 inhibitor with binding KD of 1.62 uM, inhibits OAG-stimulated Ca2+ influx with IC50 of 31.07 nM, shows >100-fold selectivity over TRPC3 and TRPC7.
    Z3571 (1 uM) specifically inhibits TRPC6-mediated Ca2+ signaling, attenuates the OAG-induced [Ca2+]i elevation in murine podocyte clone cell line MPC-5 cells, with no significant suppression of Tg- or EA-induced [Ca2+]i elevation, suggesting no detectable activity against TRPC1/4/5 channels.
    Z3571 attenuates ADR-induced injury in MPC-5 cells by targeting TRPC6.
    Z3571 concentration-dependently suppresses the expression and channel function of TRPC6 in ADR-injured podocytes.
    Z3571 suppresses TGF-β1-induced fibrosis in HK-2 cells by targeting TRPC6
    Z3571 (12.5/25/50 mg/kg)  dose-dependently restores kidney function and reduces podocyte damage in FSGS model mice.
    Z3571 significantly ameliorates kidney function and reduces renal fibrosis in mice with UUO.

    物理化学性质&存储条件

    分子量 246.27
    分子式 C13H14N2O3
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    3-[(1-methyl-1H-indole-2-carbonyl) amino] propionic acid

    参考文献

    1. Lei Zhou, et al. Biochem Pharmacol. 2025 Nov 21:117557.

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