Ponometrep (BHV-2100) | TRPM3 antagonist | Probechem Biochemicals

Chemical Structure : BHV-2100

CAS No.: 2776175-74-5

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BHV-2100 (Ponometrep, BHV2100)

货号: PC-26577Not For Human Use, Lab Use Only.

BHV-2100 (Ponometrep, BHV2100) is a selective, peripherally restricted TRPM3 antagonist, inhibits human, mouse, and rat TRPM3 with IC50 of 1-10 nM, shows >1000x selectivity vs related channels and no significant off-target liabilities.

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5 mg	￥1280	In stock
10 mg	￥1980	In stock
25 mg	￥3480	In stock
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100 mg		Get quote

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生物&药学活性

BHV-2100 (Ponometrep, BHV2100) is a selective, peripherally restricted TRPM3 antagonist, inhibits human, mouse, and rat TRPM3 with IC50 of 1-10 nM, shows >1000x selectivity vs related channels and no significant off-target liabilities.
BHV-2100 is peripherally restricted by design and displays good-excellent ADME/PK across species.
BHV-2100 has demonstrated robust and dose dependent inhibition of pain in multiple rodent models, including pregnenolone sulfate-induced pain in mice.

物理化学性质&存储条件

分子量	389.43
分子式	C18H19N3O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-N-(1-Amino-3-hydroxy-1-oxopropan-2-yl)-2-methyl-5-((2-methylthiazol-5-yl)methoxy)benzofuran-3-carboxamide

参考文献

1. Joris Vriens, et al. American Academy of Neurology Journals April 9, 2024 issue 102 (7_supplement_1) 6059.

BHV-2100 (Ponometrep, BHV2100)

生物&药学活性

物理化学性质&存储条件

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BHV-2100 (Ponometrep, BHV2100)

生物&药学活性

物理化学性质&存储条件

参考文献

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