Prion (inhibitors, antagonists, agonists)-ProbeChem.com

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Cat. No.	Product Name	Information
PC-49096	ARN1468 SERPINA3 inhibitor	ARN1468 is an anti-prion, cellular active small molecule targeting SERPINA3 (ITC KD=26 uM), decreases prion accumulation and reduces PrPSc in the ScGT1 RML cell line with EC50 of 8.64 uM.
PC-62187	DAPH-12 Prion inhibitor	DAPH-12 is a small molecule that directly inhibits and reverses prion protein Sup35 prionogenesis (IC50=0.18 uM).
PC-62186	DAPH-1 Prion inhibitor, EGFR inhibitor	DAPH-1 (CGP 52411) is a small molecule that directly inhibits prion protein Sup35 prionogenesis with IC50 of 0.58 uM, inhibits and reverses the formation of Aβ42 fibers and reduces their toxicity to neurons in culture.
PC-70278	Anle-138b Prion inhibitor, α-Synuclein inhibitor	Emrusolmin (Anle-138b) is a novel oligomer modulator that blocks the formation of pathological aggregates of prion protein (PrP(Sc)) and of α-synuclein (α-syn).
PC-60646	IND-114338 Prion inhibitor	IND-114338 is a novel antiprion compound with EC50 of 68 nM, significantly increases monoglycosylated/diglycosylated PrPSc.
PC-60645	IND125 Prion inhibitor	IND125 is a potent, brain penetrant antiprion compound with EC50 of 57 nM, prevents both PrP(Sc) accumulation and astrocytic gliosis in the cerebrum.

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