DAPH-12 |CAS:145915-63-5 Probechem Biochemicals

Chemical Structure : DAPH-12

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DAPH-12 (DAPH12)

货号: PC-62187Not For Human Use, Lab Use Only.

DAPH-12 is a small molecule that directly inhibits and reverses prion protein Sup35 prionogenesis (IC50=0.18 uM).

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生物&药学活性

DAPH-12 is a small molecule that directly inhibits and reverses prion protein Sup35 prionogenesis (IC50=0.18 uM).
Combinations of DAPH-12 and EGCG more effectively inhibits spontaneous and seeds NM fibrillization, and more effectively eliminates NM4 and NM25 than either small molecule alone.

物理化学性质&存储条件

分子量	389.411
分子式	C22H19N3O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5,6-Bis[(4-methoxyphenyl)amino]-1H-isoindole-1,3(2H)-dione

参考文献

1. Roberts BE, et al. Nat Chem Biol. 2009 Dec;5(12):936-46.

2. Wang H, et al. Proc Natl Acad Sci U S A. 2008 May 20;105(20):7159-64.

DAPH-12 (DAPH12)

生物&药学活性

物理化学性质&存储条件

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DAPH-12 (DAPH12)

生物&药学活性

物理化学性质&存储条件

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