IND125 |CAS: 2650085-35-9 Probechem Biochemicals

Chemical Structure : IND125

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IND125 (IND-125;IND125 )

货号: PC-60645Not For Human Use, Lab Use Only.

IND125 is a potent, brain penetrant antiprion compound with EC50 of 57 nM, prevents both PrP(Sc) accumulation and astrocytic gliosis in the cerebrum.

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生物&药学活性

IND125 is a potent, brain penetrant antiprion compound with EC50 of 57 nM, prevents both PrP(Sc) accumulation and astrocytic gliosis in the cerebrum.
IND125 prolongs the lives of mice expressing a chimeric human/mouse PrP transgene inoculated with Creutzfeldt-Jakob disease prions.

物理化学性质&存储条件

分子量	386.429
分子式	C21H14N4O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-(oxazol-5-yl)phenyl)-4-(3-phenylisoxazol-5-yl)thiazol-2-amine

参考文献

1. Giles K, et al. J Pharmacol Exp Ther. 2015 Oct;355(1):2-12.

IND125 (IND-125;IND125 )

生物&药学活性

物理化学性质&存储条件

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IND125 (IND-125;IND125 )

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物理化学性质&存储条件

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