| Cat. No. |
Product Name |
Information |
| PC-72880 |
PKUMDL-WQ-2201
PHGDH inhibitor
|
PKUMDL-WQ-2201 is a potent, selective, allosteric inhibitor of PHGDH, binds to allosteric site II. |
| PC-72879 |
BI-4916
PHGDH inhibitor
|
BI-4916 (BI-4916) is the prodrug of BI-4924, which is a potent, selective NADH/NAD+-competitive PHGDH inhibitor with IC50 of 2 nM. |
| PC-72878 |
BI-4924
PHGDH inhibitor
|
BI-4924 (BI 4924) is a potent, selective NADH/NAD+-competitive PHGDH inhibitor with IC50 of 2 nM. |
| PC-35907 |
WQ-2101
PHGDH inhibitor
|
WQ-2101 (WQ2101, PKUMDL-WQ-2101) is a specific, allosteric inhibitor of PHGDH with IC50 of 34.8 uM (WT PHGDH), shows dramatically reduced potenecy for mutants R134A (IC50 =141 uM) and K57AT59A (IC50=128 uM). |
| PC-62265 |
NCT-502
PHGDH inhibitor
|
NCT-502 is a small molecule 3-phosphoglycerate dehydrogenase (PHGDH) inhibitor (IC50=3.7 uM) that reduces the production of glucose-derived serine in cells and suppress the growth of PHGDH-dependent cancer cells. |
| PC-62264 |
NCT-503
PHGDH inhibitor
|
NCT-503 is a small molecule 3-phosphoglycerate dehydrogenase (PHGDH) inhibitor (IC50=2.5 uM) that reduces the production of glucose-derived serine in cells and suppress the growth of PHGDH-dependent cancer cells. |
| PC-42027 |
CBR-5884
PHGDH inhibitor
|
CBR-5884 (CBR5884) is a potent, selective, noncompetitive inhibitor of 3-phosphoglycerate dehydrogenase (PHGDH) with IC50 of 7 uM. |
| PC-23184 |
LXH-3-71
PHGDH degrader
|
LXH-3-71 is a potent mlecular glue triggers degradation of 3-phosphoglycerate dehydrogenase (PHGDH), covalently binds to Cys281 of PHGDH, triggers significant and selective degradation of PHGDH both in vitro and in vivo. |
