NCT-502 |CAS:1542213-00-2 Probechem Biochemicals

Chemical Structure : NCT-502

CAS No.: 1542213-00-2

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NCT-502 (NCT502, NCT 502 )

货号: PC-62265Not For Human Use, Lab Use Only.

NCT-502 is a small molecule 3-phosphoglycerate dehydrogenase (PHGDH) inhibitor (IC50=3.7 uM) that reduces the production of glucose-derived serine in cells and suppress the growth of PHGDH-dependent cancer cells.

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10 mg	￥1180	In stock
25 mg	￥2180	In stock
50 mg	￥3880	In stock
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生物&药学活性

NCT-502 is a small molecule 3-phosphoglycerate dehydrogenase (PHGDH) inhibitor (IC50=3.7 uM) that reduces the production of glucose-derived serine in cells and suppress the growth of PHGDH-dependent cancer cells.
NCT-502 decreases intracellular serine and glycine concentrations in MDA-MB-231 cells.
NCT-502 also reduces the PSAT1-catalyzed production of M+5-α-ketoglutarate.

物理化学性质&存储条件

分子量	395.448
分子式	C18H20F3N5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4,6-dimethyl-2-pyridinyl)-4-[5-(trifluoromethyl)-2-pyridinyl]-1-piperazinecarbothioamide

参考文献

1. Pacold ME, et al. Nat Chem Biol. 2016 Jun;12(6):452-8.

NCT-502 (NCT502, NCT 502 )

生物&药学活性

物理化学性质&存储条件

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NCT-502 (NCT502, NCT 502 )

生物&药学活性

物理化学性质&存储条件

参考文献

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