NCT-503 (NCT503)

Chemical Structure : NCT-503

CAS No.: 1916571-90-8

加入收藏

货号: PC-62264Not For Human Use, Lab Use Only.

NCT-503 is a small molecule 3-phosphoglycerate dehydrogenase (PHGDH) inhibitor (IC50=2.5 uM) that reduces the production of glucose-derived serine in cells and suppress the growth of PHGDH-dependent cancer cells.

规格	价格	库存
10 mg	￥880	In stock
25 mg	￥1480	In stock
50 mg	￥2480	In stock
100 mg	￥3980	In stock
200 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

NCT-503 (NCT503) is a small molecule 3-phosphoglycerate dehydrogenase (PHGDH) inhibitor (IC50=2.5 uM) that reduces the production of glucose-derived serine in cells and suppress the growth of PHGDH-dependent cancer cells.
NCT-503 exhibits EC50 of 8-16 uM for the PHGDH-dependent cell lines; has reasonable aqueous solubility and favorable ADME properties.
NCT-503 selectively increases necrosis in MDA-MB-468 xenografts.

物理化学性质&存储条件

分子量	408.487
分子式	C20H23F3N4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4,6-dimethyl-2-pyridinyl)-4-[[4-(trifluoromethyl)phenyl]methyl]-1-piperazinecarbothioamide

参考文献

1. Pacold ME, et al. Nat Chem Biol. 2016 Jun;12(6):452-8.

NCT-503 (NCT503)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

NCT-503 (NCT503)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.