WQ-2101 | PHGDH inhibitor | Probechem Biochemicals

Chemical Structure : WQ-2101

CAS No.: 304481-72-9

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WQ-2101 (WQ2101, WQ 2101, PKUMDL-WQ-2101)

货号: PC-35907Not For Human Use, Lab Use Only.

WQ-2101 (WQ2101, PKUMDL-WQ-2101) is a specific, allosteric inhibitor of PHGDH with IC50 of 34.8 uM (WT PHGDH), shows dramatically reduced potenecy for mutants R134A (IC50 =141 uM) and K57AT59A (IC50=128 uM).

规格	价格	库存
10 mg	￥780	In stock
25 mg	￥1280	In stock
50 mg	￥2180	In stock
100 mg	￥3580	In stock
250 mg		Get quote

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生物&药学活性

WQ-2101 (WQ2101, PKUMDL-WQ-2101) is a specific, allosteric inhibitor of PHGDH with IC50 of 34.8 uM (WT PHGDH), shows dramatically reduced potenecy for mutants R134A (IC50 =141 uM) and K57AT59A (IC50=128 uM).
WQ-2101 binds to allosteric site I, inhibits the serine biosynthesis pathway in cells.
WQ-2101 shows dose-dependent suppression effects on the cell viability at micromolar concentrations, with good selectivity for PHGDH amplified breast cancer cell lines (MDA-MB-468 and HCC70 IC50= 7.70 and 10.8 uM).
WQ-2101 selectively inhibit de novo serine synthesis in cancer cells, and reduce tumor growth in vivo.

物理化学性质&存储条件

分子量	317.257
分子式	C14H11N3O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2,4-Dihydroxy-N'-(2-hydroxy-5-nitrobenzylidene)benzohydrazide

参考文献

1. Reid MA, et al. Nat Commun. 2018 Dec 21;9(1):5442.

2. Wang Q, et al. Cell Chem Biol. 2017 Jan 19;24(1):55-65.

WQ-2101 (WQ2101, WQ 2101, PKUMDL-WQ-2101)

生物&药学活性

物理化学性质&存储条件

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WQ-2101 (WQ2101, WQ 2101, PKUMDL-WQ-2101)

生物&药学活性

物理化学性质&存储条件

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