| Cat. No. |
Product Name |
Information |
| PC-27067 |
KMG-732
Tubulin polymerization / GAK inhibitor
|
KMG-732 is a dual-targeting inhibitor of tubulin polymerization and cyclin G-associated kinase (GAK), targets the colchicine-binding site, effectively disrupts microtubule assembly and triggers mitotic arrest followed by apoptosis, significantly attenuates cancer cell migration and invasion. |
| PC-26611 |
QW-5-70
Tubulin inhibitor
|
QW-5-70 is a colchicine binding site inhibitor (CBSI) with SPR KD of 10.8 uM for colchicine site on tubulin, inhibits tubulin polymerization, disrupts microtubule networks, and induces mitotic arrest, circumvents P-gp-associated resistance. |
| PC-25976 |
Cevipabulin
Tubulin inhibitor
|
Cevipabulin (TTI-237) is a microtubule-stabilizing agent by binding to the vinblastine site, also binds to a new site on α-tubulin, shows IC50 of 18-40 nM for cytotoxicity in a panel of human tumor cell lines. |
| PC-25975 |
Paclitaxel
Tubulin inhibitor
|
Paclitaxel is a naturally occurring antineoplastic agent and tubulin polymerization stabilizer, induces both mitotic arrest and apoptotic cell death, also induces autophagy. |
| PC-25945 |
SP-1-39
Tubulin inhibitor
|
SP-1-39 is a novel colchicine-binding site inhibitor (CBSI), inhibits tubulin-polymerization, exhibits high cytotoxic activity in vitro with IC50 of 0.2 nM (PC-3/TxR). |
| PC-25919 |
Verubulin
Tubulin inhibitor
|
Verubulin (MPC-6827) is a microtubule-destabilizing agent and microtubule formation inhibitor, effectively inhibits the polymerization of tubulin in vitro, inhibits cancer cell lines regardless of the expression levels of the multidrug resistance ABC transporters MDR-1 (Pgp-1), MRP-1, and BCRP-1. |
| PC-25918 |
SB-216
Tubulin inhibitor
|
SB-216 is a potent and brain-penetrable tubulin inhibitor, inhibits cell growth and migration, and induces apoptosis with low nanomolar potencies in breast cancer brain metastasis (BCBM) models. |
| PC-25515 |
OXi8007
Tubulin inhibitor
|
OXi8007 is a vascular disrupting agent and watersoluble phosphate prodrug of OXi8006, inhibits tubulin assembly with IC50 of 1.1 uM, shows cytotoxic against DU-145 cells with GI50 of 36 nM. |
| PC-25514 |
KGP265
Tubulin inhibitor
|
KGP265 is a water-soluble phosphate prodrug salt of benzosuberene-based tubulin-binding agent KGP18. |
| PC-25513 |
OXi6197
Tubulin inhibitor
|
OXi6197 (KGP04) is the phosphate prodrug of OXi6196, which is a potent tubulin-binding agent with IC50 of 200 nM for inhibition of tubulin polymerization, rapidly releases OXi6196 in the presence of alkaline phosphatase. |
| PC-25512 |
OXi6196
Tubulin inhibitor
|
OXi6196 is a potent tubulin-binding agent with IC50 of 200 nM for inhibition of tubulin polymerization utilizing a cell-free assay. |
| PC-25361 |
Tubulin inhibitor 89
Tubulin inhibitor
|
Tubulin inhibitor 89 is a novel potent colchicine-site inhibitor of tubulin, has significant cytostatic activity against human Hela (cervical) and HCT116 (colonic) tumor cells with IC50 of 1.13 and 0.65 uM respectively, interferes with the assembly of microtubules by inhibiting PI3K/Akt signaling pathway. |
