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首页-小分子抑制剂&激动剂-Cytoskeleton/Cell Adhesion Molecules-Microtubule/Tubulin-KMG-732
KMG-732

Chemical Structure : KMG-732

CAS No.:

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KMG-732 (KMG732)

货号: PC-27067Not For Human Use, Lab Use Only.

KMG-732 is a dual-targeting inhibitor of tubulin polymerization and cyclin G-associated kinase (GAK), targets the colchicine-binding site, effectively disrupts microtubule assembly and triggers mitotic arrest followed by apoptosis, significantly attenuates cancer cell migration and invasion.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

KMG-732 is a dual-targeting inhibitor of tubulin polymerization and cyclin G-associated kinase (GAK), targets the colchicine-binding site, effectively disrupts microtubule assembly and triggers mitotic arrest followed by apoptosis, significantly attenuates cancer cell migration and invasion.

物理化学性质&存储条件

分子量 391.44
分子式 C23H17N7
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-amino-6-(1H-indazol-3-yl)-4-(1-methyl-3-phenyl-1H-pyrazol-4-yl)nicotinonitrile

参考文献

1. Seulki Park, et al. J Med Chem. 2026 Jun 15. doi: 10.1021/acs.jmedchem.6c00337.

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