QW-5-70

Chemical Structure : QW-5-70

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货号: PC-26611Not For Human Use, Lab Use Only.

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250 mg		Get quote

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生物&药学活性

QW-5-70 is a colchicine binding site inhibitor (CBSI) with SPR KD of 10.8 uM for colchicine site on tubulin, inhibits tubulin polymerization, disrupts microtubule networks, and induces mitotic arrest, circumvents P-gp-associated resistance.
QW-5-70 maintained low-nanomolar activity and remained effective in vincristine-resistant BE2C/VCR and paclitaxel-resistant PC-3/TxR cells (K-N-BE(2)-C, IC50=1.0 uM).
Unlike vincristine and paclitaxel, the activity and intracellular accumulation of QW-5-70 were unaffected by pharmacologic or genetic inhibition of P-gp, indicating effective circumvention of efflux-mediated resistance.
QW-5-70 significantly reduced colony formation and impaired migration in both parental and resistant cancer cells and induced G2–M cell-cycle arrest and mitochondrial apoptosis.
QW-5-70 significantly suppressed tumor growth in drug-resistant PC-3/TxR and BE2C/VCR xenografts, with modest weight loss and no evident histopathology in the major organs.

物理化学性质&存储条件

分子量	378.39
分子式	C20H18N4O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(4-(1H-indazol-4-yl)-1H-imidazol-2-yl)(3,4,5-trimethoxyphenyl)methanone

参考文献

1. Yang Xie, et al. Mol Cancer Ther. 2026 Apr 22:OF1-OF14.

QW-5-70

生物&药学活性

物理化学性质&存储条件

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QW-5-70

生物&药学活性

物理化学性质&存储条件

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