| Cat. No. |
Product Name |
Information |
| PC-49553 |
Nitazoxanide
HBx-DDB1 inhibitor
|
Nitazoxanide (NTX) is a thiazolide anti-infective agent that efficiently inhibits the HBV regulatory protein X (HBx)-DDB1 protein interaction, exhibits potent inhibition of both HBV and HCV replication. |
| PC-49333 |
GST-HG131
HBV antigen inhibitor
|
Zeptenstat (GST-HG131) is a specific small molecule HBV antigen inhibitor, exhibits excellent and specific HBV antigens inhibition with EC50 of 28.2 nM (HBsAg) and 16.0 nM (HBeAg), respectively. |
| PC-47007 |
DF-006
ALPK1 agonist
|
DF-006 is a small molecule, orally active Alpha-kinase 1 (ALPK1) agonist, activates ALPK1 and stimulates host innate immunity locally in liver, DF-006 enacts potent anti-HBV responses in mouse models of HBV and in primary human hepatocytes. |
| PC-38680 |
Firzacorvir
HBV inhibitor
|
Firzacorvir (ABI-H2158) is a novel potent HBV core inhibitor structurally distinct from other core inhibitors, ABI-H2158 is a pan-genotypic HBV inhibitor with EC50s ranging from 7.1 to 22 nM across HBV genotypes A-E. |
| PC-38657 |
ZINC20451377
HBsAg inhibitor
|
ZINC20451377 is a small molecule that binds to hepatitis B surface antigen (HBsAg) with high affinity (Kd=65.3 nM), reduces HBsAg levels and HBV virion secretion in cell culture model for HBV. |
| PC-38561 |
ATI-2173
HBV inhibitor
|
Fosclevudine alafenamide (ATI-2173) is a novel liver-targeted prodrug of clevudine, ATI-2173 is a selective inhibitor of HBV with EC50 of 1.31 nM in primary human hepatocytes with minimal to no toxicity. |
| PC-38419 |
Rencofilstat
Cyclophilin inhibitor
|
Rencofilstat (CRV431) is a non-immunosuppressive analogue of cyclosporine A and pan-cyclophilin inhibitor, potently inhibits cyclophilin isoforms A, B, D, and G with IC50 of 1-7 nM. |
| PC-73427 |
Linvencorvir
HBV inhibitor
|
Linvencorvir (RG7907, RG-7907) is an anti-HBV agent, functions as a HBV capsid assembly inhibitor. |
| PC-72718 |
AB-452
PAPD5/7 inhibitor
|
AB-452 (AB452) is a potent, small molecule inhibitor of noncanonical poly(A) polymerases PAPD5 and PAPD7 (PAPD5/7), inhibits PAPD5/7 enzymatic activities, reduces HBsAg in vitro (EC50=1.4/6.8 nM). |
| PC-72677 |
AB-506
HBV core protein inhibitor
|
AB-506 is a small-molecule inhibitor targeting HBV core protein, inhibits viral replication in vitro (IC50=77 nM). |
| PC-72258 |
RG7834
HBsAg inhibitor
|
RG7834 (RG-7834, RO7020322) is a potent, specific, orally bioavailable small molecule inhibitor of HBV gene expression, reduces HBV total mRNA levels with EC50 of 5.87 nM. |
| PC-35873 |
NVR 3-778
HBV capsid inhibitor
|
NVR 3-778 (NVR3-778, NVR 3778) is a small molecule inhibitor of HBV replication that targets the viral core protein, a first-in-class capsid assembly modulator. |
