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DF-006

Chemical Structure : DF-006

CAS No.: 2311947-41-6

DF-006 (DF006)

货号: PC-47007Not For Human Use, Lab Use Only.

DF-006 is a small molecule, orally active Alpha-kinase 1 (ALPK1) agonist, activates ALPK1 and stimulates host innate immunity locally in liver, DF-006 enacts potent anti-HBV responses in mouse models of HBV and in primary human hepatocytes.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    DF-006 is a small molecule, orally active Alpha-kinase 1 (ALPK1) agonist, activates ALPK1 and stimulates host innate immunity locally in liver, DF-006 enacts potent anti-HBV responses in mouse models of HBV and in primary human hepatocytes.
    DF-006 rapidly reduced serum HBV DNA, HBsAg and HBeAg levels using doses as low as 0.08, 1 and 5 μg/kg, respectively, in mouse models.
    DF-006 in combination with the HBV nucleoside reverse transcriptase inhibitor, entecavir further reduced HBV DNA.
    DF-006 also showed anti-HBV efficacy in PHH, with significant reductions of HBV DNA, at sub-nanomolar concentrations.
    DF-006 up-regulateed NF-κB-targeted genes that are involved in innate immunity.

    物理化学性质&存储条件

    分子量 805.570
    分子式 C25H34FN5O18P2S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (2S,3S,4S,5S,6S)-2-((S)-2-acetoxy-1-fluoroethyl)-6-(((((((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(mercapto)phosphoryl)oxy)(hydroxy)phosphoryl)oxy)tetrahydro-2H-pyran-3,4,5-triyl triacetate

    参考文献

    1. Xu C, et al. Hepatology. 2022 Jun 14. doi: 10.1002/hep.32614.

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