Firzacorvir (ABI-H2158)

Chemical Structure : Firzacorvir

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货号: PC-38680Not For Human Use, Lab Use Only.

Firzacorvir (ABI-H2158) is a novel potent HBV core inhibitor structurally distinct from other core inhibitors, ABI-H2158 is a pan-genotypic HBV inhibitor with EC50s ranging from 7.1 to 22 nM across HBV genotypes A-E.

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100 mg		Get quote

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生物&药学活性

Firzacorvir (ABI-H2158) is a novel potent HBV core inhibitor structurally distinct from other core inhibitors, ABI-H2158 is a pan-genotypic HBV inhibitor with EC50s ranging from 7.1 to 22 nM across HBV genotypes A-E.
ABI-H2158 inhibited HBV replication by blocking pgRNA encapsidation in induced HepAD38 cells (EC50=22 nM) and had similar potency in HBV-infected HepG2-NTCP cells (EC50=27 nM) and primary human hepatocytes (PHH) (EC50=41 nM).
ABI-H2158 also potently blocked the formation of cccDNA in de novo HBV infections with EC50s of 200 nM in HepG2-NTCP and PHH assays.
ABI-H2158 has dual mechanisms of action, inhibiting both early and late steps of the HBV replication cycle.

物理化学性质&存储条件

分子量	484.96
分子式	C18H18ClFN6O3S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2H-1,2,6-Thiadiazine-3-carboxamide, N-(3-chloro-4-fluorophenyl)tetrahydro-2-methyl-5-[5-(1-methyl-1H-imidazol-4-yl)-2-thiazolyl]-, 1,1-dioxide, (3S,5R)-

参考文献

1. Patent, WO2018160878 A1 2018-09-07.
2. Yan R, et al. Antiviral Res. 2022 Dec 9;209:105485.