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Rencofilstat

Chemical Structure : Rencofilstat

CAS No.: 1383420-08-3

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Rencofilstat (CRV431, CRV-431)

货号: PC-38419Not For Human Use, Lab Use Only.

Rencofilstat (CRV431) is a non-immunosuppressive analogue of cyclosporine A and pan-cyclophilin inhibitor, potently inhibits cyclophilin isoforms A, B, D, and G with IC50 of 1-7 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    Rencofilstat (CRV431) is a non-immunosuppressive analogue of cyclosporine A and pan-cyclophilin inhibitor, potently inhibits cyclophilin isoforms A, B, D, and G with IC50 of 1-7 nM.
    Rencofilstat (CRV431) is more than 13 times more potent than the parent compound, cyclosporine A (CsA).
    Rencofilstat (CRV431) inhibits liver HBV DNA and HBsAg, reduces liver HBV DNA levels and moderately decreased serum HBsAg levels in HBV transgenic mouse model.
    Rencofilstat (CRV431) shows potential as a drug candidate for chronic liver diseases.

    物理化学性质&存储条件

    分子量 1303.784
    分子式 C67H122N12O13
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-((7R,8R)-8-((2S,5S,8R,11S,14S,17S,20S,23R,26S,29S,32S)-5-ethyl-11,17,26,29-tetraisobutyl-14,32-diisopropyl-1,7,8,10,16,20,23,25,28,31-decamethyl-3,6,9,12,15,18,21,24,27,30,33-undecaoxo-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2-yl)-8-hydroxy-7-methyloctyl)acetamide

    参考文献

    1. Gallay P, et al. PLoS One. 2019 Jun 10;14(6):e0217433.

    2. Kuo J, et al. J Pharmacol Exp Ther. 2019 Nov;371(2):231-241.

    3. Trepanier DJ, et al. J Pharm Pharm Sci. 2018;21(1s):335s-348s.

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