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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-HBV-RG7834
RG7834

Chemical Structure : RG7834

CAS No.: 2072057-17-9

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RG7834 (RG-7834, RO7020322)

货号: PC-72258Not For Human Use, Lab Use Only.

RG7834 (RG-7834, RO7020322) is a potent, specific, orally bioavailable small molecule inhibitor of HBV gene expression, reduces HBV total mRNA levels with EC50 of 5.87 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

RG7834 (RG-7834, RO7020322) is a potent, specific, orally bioavailable small molecule inhibitor of HBV gene expression, reduces HBV total mRNA levels with EC50 of 5.87 nM.
RG7834 is highly selective for HBV and unlike current therapy inhibits the expression of viral proteins by specifically reducing HBV mRNAs.
RG7834 inhibited HBV genotypes with similar activity, reducing HBV DNA levels with EC50 of 2.2-6.0 nM, in primary human hepatocytes (PHH) infected with clinical isolates representing the most prevalent HBV genotypes A, B, C, and D.
G7834 does not interfere with the functions or expression levels of major transcription factors in hepatocytes.
RG7834 reduced HBsAg levels and other viral markers in HBV-infected human liver chimeric uPA-SCID mice.
Combination treatment with RG7834 and entecavir or interferon induced a balanced and profound reduction of both viremia and HBsAg levels.
RG7834 also disrupts the ZCCHC14-TENT4A/B interaction and prevents HAV RNA synthesis, exhibits potent antiviral activity against HAV, both in vitro and in vivo in a murine model of hepatitis A.

物理化学性质&存储条件

分子量 401.46
分子式 C22H27NO6
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(6S)-6-Isopropyl-10-methoxy-9-(3-methoxypropoxy)-2-oxo-6,7-dihydrobenzo[a]quinolizine-3-carboxylic acid

参考文献

1. JD, et al. J Hepatol. 2018 Mar;68(3):412-420.

2. Han X, et al. J Med Chem. 2018 Dec 13;61(23):10619-10634.

3. Mueller H, et al. Hepatology. 2019 Apr;69(4):1398-1411.

4. Sun L, et al. Antimicrob Agents Chemother. 2020 Dec 16;65(1):e00640-20.

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