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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-HBV-Nitazoxanide
Nitazoxanide

Chemical Structure : Nitazoxanide

CAS No.: 55981-09-4

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Nitazoxanide (NTZ, NSC 697855)

货号: PC-49553Not For Human Use, Lab Use Only.

Nitazoxanide (NTX) is a thiazolide anti-infective agent that efficiently inhibits the HBV regulatory protein X (HBx)-DDB1 protein interaction, exhibits potent inhibition of both HBV and HCV replication.

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25 mg ￥780 In stock
50 mg ￥1180 In stock
100 mg ￥1780 In stock
500 mg ￥3280 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Nitazoxanide (NTX) is a thiazolide anti-infective agent that efficiently inhibits the HBV regulatory protein X (HBx)-DDB1 protein interaction, exhibits potent inhibition of both HBV and HCV replication.
Nitazoxanide significantly restores Smc5 protein levels and suppresses viral transcription and viral protein production in the HBV minicircle system and in human primary hepatocytes naturally infected with HBV.
Nitazoxanide is active against anaerobic bacteria, protozoa, and a range of viruses in cell culture model.
Nitazoxanide is equally effective at inhibiting replication of lamivudine (LMV) and adefovir dipovoxil (ADV)-resistant HBV mutants and against 2'-C-methyl cytidine (2'CmeC) and telaprevir (VX-950)-resistant HCV mutants.
Nitazoxanide displayed synergistic interactions with LMV or ADV against HBV, and with recombinant interferon alpha-2b (IFN) or 2'CmeC against HCV.

物理化学性质&存储条件

分子量 307.28
分子式 C12H9N3O5S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-(acetyloxy)-N-(5-nitro-2-thiazolyl)-benzamide

参考文献

1. Korba BE, et al. Antiviral Res. 2008 Jan;77(1):56-63.

2. Keeffe EB, et al. World J Gastroenterol. 2009 Apr 21;15(15):1805-8.

3. Sekiba K, et al. Cell Mol Gastroenterol Hepatol. 2019;7(2):297-312.

4. Sekiba K, et al. J Hepatol. 2022 Jan;76(1):53-62.

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