Glycine Transporter (GlyT) (inhibitors, antagonists, agonists)-ProbeChem.com

Request The Product List ofGlycine Transporter (GlyT) Glycine Transporter (GlyT)

Cat. No.	Product Name	Information
PC-38397	Iclepertin GlyT1 inhibitor	Iclepertin (BI 425809) is a potent, selective and oral glycine transporter 1 (GlyT1) inhibitor with IC50 of 5.2 nM in rat primary neurons and 5.0 nM in human SK‐N‐MC cells (3H‐glycine uptake).
PC-35393	GlyT1 inhibitor 46 GlyT1 inhibitor	GlyT1 inhibitor 46 is a novel potent, selective, orally available inhibitor of glycine transporter-1 (GlyT1) with IC50 of 38 and 21 nM for rat and human GlyT1, respectively.
PC-62960	ALX-5407 hydrochloride GlyT1 inhibitor	ALX-5407 hydrochloride is a potent, selective, orally active inhibitor of GlyT1 glycine transporter with IC50 of 3 nM.
PC-61835	PF-03463275 GlyT1 inhibitor	PF-03463275 (PF 3463275) ia an orally bioavailable, centrally penetrant, potent, reversible, selective, and competitive inhibitor of the human GlyT1 transporter with Ki of 13 nM.
PC-61461	ALX5407 GlyT1 inhibitor	ALX 5407 ((+)-NFPS) is a potent, selective GlyT1 inhibitor that demonstrates >10-fold greater activity in in vitro functional glycine reuptake assay than racemic (±)-NFPS.
PC-61460	NFPS GlyT1 inhibitor	NFPS (ALX-5407) is a potent, selective GlyT1 inhibitor with IC50 of 2.8 and 9.8 nM for hGlyT1 and rGlyT1 respectively, >5,000-fold selectivity over rGlyT2.
PC-61459	TASP0315003 GlyT1 inhibitor	A potent, selective, orally available GlyT1 inhibitor with IC50 of 1.6 nM, weakly inhibits rat GlyT2 (IC50=138 nM).
PC-61458	PF-0346275 GlyT1 inhibitor	PF-0346275 is a potent, selective, orally available GlyT1 inhibitor with Ki of 11.6 nM, without activity against GlyT2 (IC50>10 uM).
PC-61457	DCCCyB GlyT1 inhibitor	DCCCyB is a potent, selective, orally available GlyT1 inhibitor with IC50 of 29 nM, demonstrates excellent in vivo occupancy of GlyT1 transporters in vivo.
PC-61002	ASP2535 GlyT1 inhibitor	A potent, selective, brain permeable, orally available glycine transporter-1 (GlyT1) inhibitor with IC50 of 92 nM (rat GlyT1), 50-fold selectivity over GlyT2.
PC-60977	AMG747 GlyT1 inhibitor	AMG747 (Tilapertin) is a nanomolar potent, selective, and orally bioavailable glycine transporter type-1 (GlyT1) inhibitor for the treatment of negative symptoms associated with schizophrenia.
PC-60676	GSK494581A GlyT1 inhibitor	GSK 494581A is a potent, specific and mixed glycine transporter subtype 1 (GlyT1) inhibitor (pIC50=7.7) and GPR55 agonist (pEC50=6.5).

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