NFPS | GlyT1 inhibitor | Probechem Biochemicals

Chemical Structure : NFPS

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NFPS ((Rac)-ALX 5407, ALX5407, (±)-NFPS)

货号: PC-61460Not For Human Use, Lab Use Only.

NFPS (ALX-5407) is a potent, selective GlyT1 inhibitor with IC50 of 2.8 and 9.8 nM for hGlyT1 and rGlyT1 respectively, >5,000-fold selectivity over rGlyT2.

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生物&药学活性

NFPS ((Rac)-ALX 5407) is a potent, selective GlyT1 inhibitor with IC50 of 2.8 and 9.8 nM for hGlyT1 and rGlyT1 respectively, >5,000-fold selectivity over rGlyT2.
NFPS inhibits glycine transport by the GlyT1a, b and c subtypes of glycine transporters, but has no effect on the GLYT2a subtype of transporter.
NFPS reverses PCP-induced changes in EEG power spectra in conscious rats (1-10 mg/kg i.p.), significantly enhances long-term potentiation in the hippocampal dentate gyrus in vivo.

物理化学性质&存储条件

分子量	393.45
分子式	C24H24FNO3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[3-([1,1-Biphenyl]-4-yloxy)-3-(4-fluorophenyl)propyl]-N-methylglycine

参考文献

1. Aubrey KR, et al. Br J Pharmacol. 2001 Dec;134(7):1429-36.

2. Harsing LG Jr, et al. Pharmacol Biochem Behav. 2003 Mar;74(4):811-25.

3. Bergeron R, et al. Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15730-4.

4. Kinney GG, et al. J Neurosci. 2003 Aug 20;23(20):7586-91.

NFPS ((Rac)-ALX 5407, ALX5407, (±)-NFPS)

生物&药学活性

物理化学性质&存储条件

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NFPS ((Rac)-ALX 5407, ALX5407, (±)-NFPS)

生物&药学活性

物理化学性质&存储条件

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