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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-Glycine Transporter (GlyT)-AMG747
AMG747

Chemical Structure : AMG747

CAS No.: 1000690-85-6

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AMG747 (Tilapertin, AMG-747)

货号: PC-60977Not For Human Use, Lab Use Only.

AMG747 (Tilapertin) is a nanomolar potent, selective, and orally bioavailable glycine transporter type-1 (GlyT1) inhibitor for the treatment of negative symptoms associated with schizophrenia.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    AMG747 (Tilapertin) is a nanomolar potent, selective, and orally bioavailable glycine transporter type-1 (GlyT1) inhibitor for the treatment of negative symptoms associated with schizophrenia.
    AMG747 (Tilapertin) dose-dependently increases cerebrospinal fluid (CSF) glycine concentration in rats and humans.

    物理化学性质&存储条件

    分子量 378.395
    分子式 C20H21F3N2O2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1-Piperazineacetic acid, 4-[(R)-phenyl[3-(trifluoromethyl)phenyl]methyl]-

    参考文献

    1. Dunayevich E, et al. Schizophr Res. 2017 Apr;182:90-97.

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