| Cat. No. |
Product Name |
Information |
| PC-28280 |
FXIa inhibitor SB-01
Factor XIa inhibitor
|
FXIa inhibitor SB-01 is a potent, selective, allosteric inhibitor of human factor XIa (FXIa) inhibitor with IC50 of 130 nM, displays potent antithrombotic activity. |
| PC-28140 |
FXII900
Factor XII inhibitor
|
FXII900 is a potent, selective cyclic peptide coagulation factor XII (FXII) inhibitor with Ki of 0.37 nM and 0.45 nM for human and mouse FXIIa, >100,000-fold selectivity over other plasma proteases. |
| PC-26359 |
Tedixaban
FXa inhibitor
|
Tedixaban (DD217) is a highly potent, selective Factor Xa (FXa) inhibitor with IC50 of 0.5 nM, doubled the prothrombin time (PTx2) value of 0.08 uM, a potent anticoagulant acting compound. |
| PC-24671 |
BAY 3389934
FIIa/Xa inhibitor
|
BAY 3389934 is a potent and highly selective, direct dual FIIa/Xa inhibitor with IC50 of 4.9/0.66 nM (in buffer) and 22/9.2 nM (in plasma) respectively. |
| PC-73462 |
Milvexian
Factor XIa inhibitor
|
Milvexian (BMS-986177, JNJ-70033093) is a highly potent, reversible, orally bioavailable factor XIa (FXIa) inhibitor with Ki of 0.11 and 0.38 nM for human and rabbit FXIa, respectively. |
| PC-73137 |
Asundexian
FXIa inhibitor
|
Asundexian (BAY2433334) is a highly potent, selective and orally active inhibitor of Factor XIa (FXIa) with IC50 of 0.92 nM. |
| PC-72148 |
ZED3197
FXIIIa inhibitor
|
ZED3197 (ZED-3197) is a novel peptidomimetic direct-acting, potent and selective inhibitor of human FXIIIa, inhibits human plasma derived FXIII‐A2B2 and the recombinant cellular form (FXIII‐A2) with IC50 of 10 and 14 nM, respectively. |
| PC-35604 |
Zifaxaban
FXa inhibitor
|
Zifaxaban is a novel, potent, selective, direct and oral factor Xa (FXa) inhibitor with IC50 of 11.1 nM (human FXa), displays >10,000-fold selectivity than other serine proteases. |
| PC-63565 |
BMS-654457
FXa inhibitor
|
BMS-654457 is a potent, reversible and direct inhibitor of factor XIa (FXa) with Ki of 0.4 nM. |
| PC-63359 |
Letaxaban
FXa inhibitor
|
Letaxaban (TAK-442, TAK442) is a potent, selective and direct factor Xa (FXa) inhibitor with Ki of 1.8 nM for hFXa, >440-fold selectivity than thrombin and negligible effects on trypsin, plasmin, and tPA. |
| PC-62006 |
BMS-962212
FXIa inhibitor
|
BMS-962212 is a potent, highly selective and reversible small molecule coagulation Factor XIa (FXIa) inhibitor with Ki of 0.7 nM. |
| PC-60995 |
Darexaban
FXa inhibitor
|
Darexaban (YM150) is potent, selective and orally available factor Xa (FXa) inhibitor with IC50 of 54.6 nM. |
