BMS-654457 |CAS:1004551-41-0 Probechem Biochemicals

Chemical Structure : BMS-654457

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BMS-654457 (BMS654457)

货号: PC-63565Not For Human Use, Lab Use Only.

BMS-654457 is a potent, reversible and direct inhibitor of factor XIa (FXa) with Ki of 0.4 nM.

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生物&药学活性

BMS-654457 is a potent, reversible and direct inhibitor of factor XIa (FXa) with Ki of 0.4 nM; shows high potency in the prolongation of aPTT in human and rabbit plasma (EC2X of 2.2 and 2.4 uM, respectively) without changing prothrombin time; increases bleeding time (BT), BMS-654457 is effective in the prevention of arterial thrombosis in rabbits with limited effects on BT.

物理化学性质&存储条件

分子量
分子式
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(+) 3'-(6-carbamimidoyl-4-methyl-4-phenyl-1,2,3,4-tetrahydro-quinolin-2-yl)-4-carbamoyl-5'-(3-methyl-butyrylamino)-biphenyl-2-carboxylic acid

参考文献

1. Wong PC, et al. J Thromb Thrombolysis. 2015 Nov;40(4):416-23.

BMS-654457 (BMS654457)

生物&药学活性

物理化学性质&存储条件

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BMS-654457 (BMS654457)

生物&药学活性

物理化学性质&存储条件

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