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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Factor Xa-BMS-654457
BMS-654457

Chemical Structure : BMS-654457

CAS No.: 1004551-41-0

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BMS-654457 (BMS654457)

货号: PC-63565Not For Human Use, Lab Use Only.

BMS-654457 is a potent, reversible and direct inhibitor of factor XIa (FXa) with Ki of 0.4 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    BMS-654457 is a potent, reversible and direct inhibitor of factor XIa (FXa) with Ki of 0.4 nM.
    BMS-654457 shows high potency in the prolongation of aPTT in human and rabbit plasma (EC2X of 2.2 and 2.4 uM, respectively) without changing prothrombin time.
    BMS-654457 increases bleeding time (BT), BMS-654457 is effective in the prevention of arterial thrombosis in rabbits with limited effects on BT.

    物理化学性质&存储条件

    分子量 603.72
    分子式 C36H37N5O4
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    3'-((2S,4R)-6-Carbamimidoyl-4-methyl-4-phenyl-1,2,3,4-tetrahydroquinolin-2-yl)-4-carbamoyl-5'-(3-methylbutanamido)-[1,1'-biphenyl]-2-carboxylic acid

    参考文献

    1. Wong PC, et al. J Thromb Thrombolysis. 2015 Nov;40(4):416-23.

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