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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Factor Xa-Milvexian
Milvexian

Chemical Structure : Milvexian

CAS No.: 1802425-99-5

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Milvexian (BMS-986177, JNJ-70033093)

货号: PC-73462Not For Human Use, Lab Use Only.

Milvexian (BMS-986177, JNJ-70033093) is a highly potent, reversible, orally bioavailable factor XIa (FXIa) inhibitor with Ki of 0.11 and 0.38 nM for human and rabbit FXIa, respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    Milvexian (BMS-986177, JNJ-70033093) is a highly potent, reversible, orally bioavailable factor XIa (FXIa) inhibitor with Ki of 0.11 and 0.38 nM for human and rabbit FXIa, respectively.
    Milvexian (BMS-986177, JNJ-70033093) increased activated partial thromboplastin time (APTT) without changing prothrombin time and potently prolonged plasma APTT in humans and rabbits.
    Milvexian (BMS-986177, JNJ-70033093) is an effective antithrombotic agent with limited impact on hemostasis, even when combined with aspirin in rabbits.
    Milvexian (BMS-986177, JNJ-70033093) is a clinical candidate for the prevention and treatment of thromboembolic disorders.

    物理化学性质&存储条件

    分子量 626.450
    分子式 C28H23Cl2F2N9O2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (6R,10S)-10-[4-[5-Chloro-2-(4-chloro-1H-1,2,3-triazol-1-yl)phenyl]-6-oxo-1(6H)-pyrimidinyl]-1-(difluoromethyl)-1,4,7,8,9,10-hexahydro-6-methyl-11,15-metheno-15H-pyrazolo[4,3-b][1,7]diazacyclotetradecin-5(6H)-one

    参考文献

    1. Perera V, et al. Sci Rep. 2022 Mar 25;12(1):5165.

    2. Weitz JI, et al. N Engl J Med. 2021 Dec 2;385(23):2161-2172.

    3. Dilger AK, et al. J Med Chem. 2022 Feb 10;65(3):1770-1785.

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