Darexaban (YM150) | FXa inhibitor | Probechem Biochemicals

Chemical Structure : Darexaban

CAS No.: 365462-23-3

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Darexaban (YM150, YM-150)

货号: PC-60995Not For Human Use, Lab Use Only.

Darexaban (YM150) is potent, selective and orally available factor Xa (FXa) inhibitor with IC50 of 54.6 nM.

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10 mg	￥1280	In stock
25 mg	￥2180	In stock
50 mg	￥3580	In stock
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生物&药学活性

Darexaban (YM150) is potent, selective and orally available factor Xa (FXa) inhibitor with IC50 of 54.6 nM.
Darexaban (YM150) displays high selectivities over other related serine proteases, such as trypsin, thrombin and kallikrein (IC50>10 uM).
Darexaban (YM150) demonstrates potent anticoagulant activities both in vitro and in vivo, shows potential for prevention and treatment of thromboembolic diseases.

物理化学性质&存储条件

分子量	474.561
分子式	C27H30N4O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[2-hydroxy-6-(4-methoxybenzamido)phenyl]-4- (4-methyl-1,4-diazepan-1-yl)benzamide

参考文献

1. Hirayama F, et al. J Med Chem. 2011 Dec 8;54(23):8051-65.

2. Iwatsuki Y, et al. Eur J Pharmacol. 2011 Dec 30;673(1-3):49-55.

3. Funatsu T, et al. J Thromb Haemost. 2012 Apr;10(4):703-5.

4. Steg PG, et al. Eur Heart J. 2011 Oct;32(20):2541-54.

Darexaban (YM150, YM-150)

生物&药学活性

物理化学性质&存储条件

参考文献

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Darexaban (YM150, YM-150)

生物&药学活性

物理化学性质&存储条件

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