Darexaban |CAS:365462-23-3 Probechem Biochemicals

Chemical Structure : Darexaban

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Darexaban (YM150;YM-150;YM 150)

货号: PC-60995Not For Human Use, Lab Use Only.

A potent, selective and orally available factor Xa (FXa) inhibitor with IC50 of 54.6 nM.

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生物&药学活性

A potent, selective and orally available factor Xa (FXa) inhibitor with IC50 of 54.6 nM; displays high selectivities over other related serine proteases, such as trypsin, thrombin and kallikrein (IC50>10 uM); demonstrates potent anticoagulant activities both in vitro and in vivo, shows potential for prevention and treatment of thromboembolic diseases.

Thrombosis

Phase 2 Discontinued

物理化学性质&存储条件

分子量	474.561
分子式	C27H30N4O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[2-hydroxy-6-(4-methoxybenzamido)phenyl]-4- (4-methyl-1,4-diazepan-1-yl)benzamide

参考文献

1. Hirayama F, et al. J Med Chem. 2011 Dec 8;54(23):8051-65.

2. Iwatsuki Y, Eur J Pharmacol. 2011 Dec 30;673(1-3):49-55.

3. Funatsu T, et al. J Thromb Haemost. 2012 Apr;10(4):703-5.

4. Steg PG, et al. Eur Heart J. 2011 Oct;32(20):2541-54.

Darexaban (YM150;YM-150;YM 150)

生物&药学活性

物理化学性质&存储条件

参考文献

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Darexaban (YM150;YM-150;YM 150)

生物&药学活性

物理化学性质&存储条件

参考文献

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