| Cat. No. |
Product Name |
Information |
| PC-22271 |
MMPIP hydrochloride
mGluR7 antagonist
|
MMPIP hydrochloride is a selective, allosteric metabotropic glutamate receptor 7 (mGluR7) antagonist / negative allosteric modulator with Kb value of 24-30 nM. |
| PC-22232 |
AZ12216052
mGluR8 PAM
|
AZ12216052 is potent, selective positive allosteric modulator of mGluR8, potentiates the effect of 300 nM glutamate with EC50 of 1.0 uM in [35S]GTPγS binding assays. |
| PC-20614 |
CVN636
mGluR7 agonist
|
CVN636 is a potent, selective, CNS penetrant and allosteric agonist of mGluR7 with EC50 of 7 and 2 nM for human and mouse mGluR7, respectively. |
| PC-20314 |
JNJ-42491293
mGlu2 ago-PAM
|
JNJ-42491293 (JNJ 42491293) is a potent, mGlu2-selective allosteric agonist and positive allosteric modulator (ago-PAM). |
| PC-49747 |
Mavoglurant
mGlu5 NAM
|
AFQ056 (Mavoglurant, AFQ-056) is a potent, subtype-selective and non-competitive inhibitor of mGluR5 with IC50 of 30 nM. |
| PC-49746 |
HTL14242
mGlu5 NAM
|
HTL14242 (HTL0014242) a potent, selective mGlu5 negative allosteric modulator (NAM) with pKi of 9.3 and pIC50 of 9.2, shows high selectivity within the metabotropic family of GPCRs. |
| PC-49593 |
VU6027459
mGlu7 PAM
|
VU6027459 is a potent, selective and CNS-penetrant mGlu7 positive allosteric modulator (PAM) with EC50 of 1.6 uM (rat mGlu7). |
| PC-49586 |
VU6046980
mGlu7 PAM
|
VU6046980 is a potent, selective and in vivo active mGlu7 positive allosteric modulator (PAM) with EC50 of 0.15 uM (rat mGlu7). |
| PC-49074 |
VU0360172
mGlu5 PAM
|
VU0360172 is a selective mGlu5 receptor positive allosteric modulator (PAM) with EC50 of 16 nM, Ki of 195 nM. |
| PC-49069 |
Dipraglurant
mGlu5 NAM
|
Dipraglurant (ADX48621) is a negative allosteric modulator (NAM) of metabotropic glutamate 5 (mGlu5) receptor with IC50 of 21 nM. |
| PC-38454 |
ML254
mGlu5 PAM
|
ML254 (VU0430644) is a potent, selective metabotropic glutamate receptor 5 (mGlu5) positive allosteric modulator with EC50 of 9.3 nM. |
| PC-73234 |
Decoglurant
mGluR2/3 NAM
|
Decoglurant (RO4995819) is a negative allosteric modulator of mGluR2 and mGluR3 with antidepressant effect. |
