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首页-小分子抑制剂&激动剂-GPCR-mGluR-VU6023326
VU6023326

Chemical Structure : VU6023326

CAS No.: 2839123-01-0

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VU6023326 (VU326)

货号: PC-22900Not For Human Use, Lab Use Only.

VU6023326 is a potent, selective, dual mGlu2/mGlu3 positive allosteric modulator with EC50 of 63/384 nM, respectively, potentiates group II mGlu receptor agonist Ca2+ signaling in PFC pyramidal cells.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

VU6023326 is a potent, selective, dual mGlu2/mGlu3 positive allosteric modulator with EC50 of 63/384 nM, respectively, potentiates group II mGlu receptor agonist Ca2+ signaling in PFC pyramidal cells.

物理化学性质&存储条件

分子量 444.52
分子式 C25H32O7
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(R)-3-(3-(4-(3,3-dimethylbutanoyl)-3-hydroxy-2-methylphenoxy)-2-methylpropoxy)-4-methoxybenzoic acid

参考文献

1. Yousuke Yamada, et al. Bioorg Med Chem Lett. 2021 Oct 15:50:128342.

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